Tag: anticholinergic effects

Anticholinergic Effects of Antihistamines: Dry Mouth, Constipation, Urinary Issues
17 January 2026

Anticholinergic Effects of Antihistamines: Dry Mouth, Constipation, Urinary Issues

First-generation antihistamines like Benadryl can cause dry mouth, constipation, and urinary issues by blocking acetylcholine receptors. Second-generation options like Zyrtec and Allegra offer the same allergy relief without these risks.

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First-Generation Antihistamines: Why Severe Drowsiness and Brain Fog Are Common Side Effects
29 December 2025

First-Generation Antihistamines: Why Severe Drowsiness and Brain Fog Are Common Side Effects

First-generation antihistamines like Benadryl cause severe drowsiness and brain fog because they cross into the brain. They also trigger anticholinergic side effects like dry mouth, blurred vision, and memory issues-especially dangerous for older adults. Safer alternatives exist.

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